Manila Science High School (or simply MaSci to its students) is the pilot science high school in Manila, Philippines. It is located in Taft Avenue corner Padre Faura Street in Ermita, Manila, and established on October 1, 1963.
The new millennium ushered in the arrival of Mrs. Susan A. Yano, fourth principal, the completion of the Antonio Maceda Building and the revival of the Manila Science High School Alumni Association. Mrs. Susan A. Yano opted for an early retirement. Ms. Edna P. Parcon, Math Department Head III, was then assigned Officer-in-Charge from July 18, 2002 to January 13, 2003, together with Ms. Betty de la Cruz, Science Supervisor, assigned Supervisor-in-Charge from October 13, 2002 to January 13, 2003.
Taking the helm of the school was the fifth principal, Mrs. Rosita Herson. She worked from the year 2004-2006 before being promoted and transferred to another school.
The Manila Science High School is currently under the leadership of a new principal, Mrs. Salud S Sabado.