Sampaloc is a district of Manila which is primarily a residential and educational center. Part of the Malacañang Palace is located in Sampaloc. The University of Santo Tomas, part of the University Belt, the famous Dangwa flower market at Dimasalang Street and the former colonial mansion now called Windsor Inn in Maceda Street (named after a famous politician from the Maceda family who comes from this district, this street used to be known as "Washington Street" in the American colonial era in honor of U.S. President George Washington)which is popular with backpackers and budget travellers. Nearby is the La Loma area, famous for its open-air lechon (roast pig) restaurants.
The Dangwa flower market is famous for selling cut flower from all over the Philippines and is open 24 hours a day. It is located beside the Dangwa Bus Station.
Among the main throughfares of this district are Dapitan Street, Laong-Laan Street, Dimasalang Street and España Boulevard. The notable high school is Ramon Magsaysay High School which is along España Boulevard.